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Anticonvulsant Screening Program
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Standard Anti-Ictal Screening
Models of Pharmacoresistance
Identification/Differentiation
Screening for Related Indications
Special Capabilities and Studies under Development
Experimental Animals and Animal Care
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Public Access to Neuroactive & Anticonvulsant Chemical Evaluations(PANAChE) Line  
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Welcome to the PANAChE database. 

This resource contains public and non-confidential chemical structures and biological data for compounds which have been screened for efficacy and toxicity in animal models of epilepsy and related seizure disorders as part of the Anticonvulsant Screening Program (ASP) at the National Institute of Neurological Disorders and Stroke. This database is being populated dynamically, beginning with known drugs in the public domain. Compounds submitted to the ASP for testing are included only with permission from the supplier. In addition to structural information, you will find biological data for each compound. In vivo models in mice and rats include the Maximal Electroshock (MES), subcutaneous Metrazol (scMET), and the rotorod test for toxicity using various methods of drug administration. Some compounds may have additional in vivo data from the 6Hz psychomotor seizure model, the hippocampal kindled rat model, the corneal kindled mouse model, the seizure threshold test , the Frings audiogenic seizures, the Morris water maze model, and in vitro results from electrophysiology studies and the spontaneous bursting model of pharmacoresistance.


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* Public Access to Neuroactive & Anticonvulsant CHemical Evaluations (PANAChE) database
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