For Layout
Skip Navigation National Institute of Neurological Disorders and Stroke Logo Link to NIH Link to NINDS Link to PANAChE
This table and all tables within this table are designed for layout purposes.
Anticonvulsant Screening Program
HomeHome
Search
ModelsCollapse
ModelsExpand
Standard Anti-Ictal Screening
Models of Pharmacoresistance
Identification/Differentiation
Screening for Related Indications
Special Capabilities and Studies under Development
Experimental Animals and Animal Care
ContactNo Expand Option
DisclaimerNo Expand Option
AccessiblityNo Expand Option
Privacy NoticeNo Expand Option
Feedback?
Switch to Simple Menu
Switch to Simple Menu




Adobe Reader Icon Adobe Reader External Website Policy
MS Word Viewer Icon MS Word Viewer Icon External Website Policy
For Layout
PANAChE ID / ASP ID: 47 Line  
For Layout
 
Aspirin
Ecotrin
2-(acetyloxy)benzoic acid
Substance Information
Structure
Chemical Structure of Aspirin

For Layout
PANAChE ID 47
Molecular Weight 180.1574
Molecular Formula C9H8O4
Smiles CC(=O)Oc1ccccc1C(O)=O
Chemical Class Salicyclic acid
Therapeutic Class Anti-inflammatory
CAS No 50782
Stereotype no_comment
Salt
PubChem ID 177513150
Bioactivity
For Layout
For Layout
Maximum Electroshock Model Subcutaneous Metrazol Model Toxicity (rotorod-mouse,ataxia-rat)
Mouse i.p. Screen No Activity No Activity See report(s)
Mouse i.p. ED50 - - -
Mouse p.o. ED50 - - -
Rat p.o. Screen See reports See reports See reports
Rat p.o. ED50 - - -
Rat i.p. Screen - - - -
Rat.i.p. ED50 - - -
For Layout
For Layout
Kindled Rat/Mouse
Rat Hippocampal Screen - Mouse Corneal -
Rat Hippocampal Toxicity - Rat Hippocampal Afterdischarge Threshold - -
Rat Hippocampal ED50 - Rat LTG-Resistant Amygdala -
For Layout
For Layout
For Layout
Subcutaneous Bicuculline Model Subcutaneous Picrotoxin Model
Mouse i.p. - -
For Layout
For Layout
Threshold Electro Convulsive Model
Threshold Tonic Extension -
For Layout
For Layout
For Layout
Pilocarpine Induced Status Prevention (PISP)
0 min Screen See report
0 min ED50 -
30 min Screen -
30 min ED50 -
EEG Study -
For Layout
For Layout
Neuroprotection - Hippocampal slice culture
Kainate -
NMDA No Neuroprotection observed
For Layout
For Layout
For Layout
Spatial Learning & Memory
Morris Water Maze -
For Layout
For Layout
For Layout
6Hz Model
Screen See report
ED50 -
For Layout
For Layout
Pain
Mouse Formalin See report
Rat Sciatic Ligation -
For Layout
For Layout
Electrophysiology
Kainate/Na+/GABA/NMDA -
Spontaneous Burst -
For Layout
For Layout
For Layout
i.v. Metrazol Infusion Model
Time to first twitch/clonus - 
For Layout
For Layout
Frings Audiogenic Sezisure Model
ED50 -
 
For Layout
Test Report in PDF format
For Layout
Solvent Code Description
ACN Acetonitrile
DMF Dimethyl Formamide
DMSO Dimethyl Sulfoxide
HPC Hydroxypropyl Cellulose
MC Methyl Cellulose
MEOH Methanol
MP 1-methyl-2-pyrrolidone (MP)
OTH Other
PEG Polyethylene Glycol
SAL Saline
WAT Water
For Layout
Solvent Prep Code Description
HT Heat
M&P Mortar & pestle
SB sonabath
TW Tween (will include a number which indicates concentration, ie/ TW20 or TW80)
TT Test tube

Note: PANAChE ID, ADD ID and ASP ID are the same.
Display PDF Control
** Test has been done more than once. The data displayed represent information collected from the most recent experiment.
For Layout
Test Description
Test 1 is an initial screen for anticonvulsant activity in the MES and scMET models combined with an initial assessment of toxicity in mice via i.p. injection. The data for each condition is presented as N/F, where N=number of animals protected and F=number of animals tested. For tests of toxicity (TOX), N=number of animals displaying toxic effects. Codes in the C column refer to comments from the experiment and are defined in the comments section if necessary. Presence of an asterisk (*) indicates that there are multiple comment codes. Any deaths are noted.
Line
* Public Access to Neuroactive & Anticonvulsant CHemical Evaluations (PANAChE) database
H H S Logo - link to U. S. Department of Health and Human Services      NINDS logo Usa.gov Logo - USA.gov is the U.S. government's official web portal to all federal, state and local government web resources and services.