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Standard Anti-Ictal Screening Line  
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Qualitative Screens in MES, scMET and Toxicity (rat, mouse, i.p., p.o.)
This test is an initial screen for anticonvulsant activity in the MES and scMET models combined with an initial assessment of toxicity. The data for each condition is presented as N/F, where N=number of animals protected and F=number of animals tested.  For tests of toxicity (TOX), N=number of animals displaying toxic effects.  Codes in the C column refer to comments from the experiment and are defined in the comments section if necessary. Presence of an asterisk (*) indicates that there are multiple comment codes. Any deaths are noted.

Quantitative Screens in MES, scMET and Toxicity (rat, mouse, i.p., p.o.)
This test is designed to quantify the anti-convulsant and toxic effects of a test compound. The time to peak effect (TPE) is measured first at a fixed dose. The data for each time point is presented as N/F, where N=number of animals protected and F=number of animals tested. For tests of toxicity (TOX), N=number of animals displaying toxic effects. The ED50 for MES, scMET and toxicity (TOX) are measured at the TPE, and descriptive statistics are found in the “ED50 Values” Section. The raw data used to determine these values are found under “ED50 Biological Response”. Codes in the C column refer to comments from the experiment and are defined in the comments section if necessary. Presence of an asterisk (*) indicates that there are multiple comment codes. Any deaths are noted.
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Last updated: 20 Nov 2013
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* Public Access to Neuroactive & Anticonvulsant CHemical Evaluations (PANAChE) database
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