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Identification/Differentiation Purposes Line  
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The Chemoconvulsant Tests
Assessment of the effect of an investigational compound against the chemoconvulsants, bicuculline and picrotoxin. (More detail)

Threshold Tonic Extension (TTE) Test
The threshold tonic extension test is a nonselective, electroconvulsive seizure model that is usually used only with those compounds that are inactive in the MES and scMet tests.  (More detail)

The Frings Audiogenic Seizure-Susceptible Mouse Model
Examines the ability of an investigational drug to alter the onset and/or severity of seizures in a genetic mouse model of seizure susceptibility.(More detail)

The In Vitro Mechanism of Action Test
Assessment of the in vitro effect of an investigational compound on voltage-gated sodium channels and receptor-gated ion channels. (More detail)

The Morris Water Maze Model
Assessment of the effect of an investigational compound on spatial learning and memory, a measure of cognitive function, in rats. (More detail)
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Last updated: 25 Mar 2016
* Public Access to Neuroactive & Anticonvulsant CHemical Evaluations (PANAChE) database
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