Identification of a therapy that can prevent, or modify epilepsy is a major goal of the epilepsy community. The aim of disease prevention research is to identify therapies that when given after a precipitating event for a limited time period prevent the development of epilepsy. To identify therapies that can modify or cure epilepsy, an investigational treatment is initiated after the disease is established and its ability to prevent seizures from reoccurring, reduce seizure burden, and alter responsiveness of drug resistant seizures is measured in absence of further treatment (Kaminski et al., 2014, Pitkänen et al., 2015; Loscher, 2020; Galanopoulou et al., 2021).